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OpenDDE

Independent 655M-parameter open model in the AlphaFold3 family

OpenDDE is an independent open-source reimplementation of the AlphaFold3 architecture published by Aureka Research under Apache 2.0. It folds proteins together with ligands, nucleic acids and modified residues through a two-stage trunk and diffusion decoder. Its 655.8M-parameter checkpoint is one of the largest fully open models in this family.

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At a glance

Input
Sequences and ligands (FASTA, SDF)
Output
All-atom complex (PDB)
Developed by
Aureka Research
Published
Aureka Research, 2025 · 2025
#open-source#co-folding#all-atom

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