NA-MPNN
Joint design of protein and nucleic-acid sequences
NA-MPNN extends the MPNN design engine to nucleic acids, designing protein and RNA or DNA sequences jointly in a single run. Nucleic acids become full design positions rather than fixed context, enabling binders and enzymes that are co-designed with their targets. The first MPNN engine for protein–RNA and protein–DNA complexes.
NA-MPNN is live on FoldForge — load a structure, mark what to redesign, and press Design.
At a glance
- Input
- Protein–nucleic-acid complex (PDB)
- Output
- Designed protein & NA sequences (FASTA)
- Developed by
- Baker Lab, UW
- Published
- Dauparas et al., bioRxiv 2025 · 2025
#sequence-design#nucleic-acids#inverse-folding
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