MembraneMPNN

Membrane-aware design with environment labels

MembraneMPNN designs sequences for membrane proteins with explicit environment awareness: label residues as buried in the bilayer, at the interface, or soluble — globally per chain or residue by residue — and the engine places hydrophobic and polar side chains where the membrane demands them. The right design engine for receptors, channels and transporters.

MembraneMPNN is live on FoldForge — load a structure, mark what to redesign, and press Design.