Molecular render representing IntelliFold-2

IntelliFold-2

Compact AlphaFold3-family folder with widened trunk representations

IntelliFold-2 is an Apache-2.0 model that runs the AlphaFold3 module tree with its own widened trunk: a 512-channel pair representation against AlphaFold3's 128. It folds proteins with ligands, DNA, RNA and modified residues and returns confidence scores with each model. A fully open alternative for all-atom complex prediction.

IntelliFold-2 is live on FoldForge — paste a sequence and press Fold.

At a glance

Input
Sequences and ligands (FASTA, SDF)
Output
All-atom complex (PDB)
Developed by
intelligenAI
Published
intelligenAI, 2025 · 2025
#open-source#co-folding#all-atom